Everything about Avermectin totally explained
Avermectin is a family of
anti-parasitic drugs whose analogues include
ivermectin,
selamectin,
doramectin and
abamectin.
Avermectin therapy for rodent fur mite infestation
A commonly used therapy in recent times has been based on oral or parenteral administration of avermectins, which are macrocyclic
lactones produced by fermentation of the soil micro-organism
Streptomyces avermitilis. They show activity against a broad range of
nematodes and
arthropod parasites of domestic animals at dose rates of 300 microgram/kg or less. Unlike the
macrolide or
polyene antibiotics, they lack significant antibacterial or antifungal activity (Hotson, 1982).
Avermectin therapy isn't without its drawbacks. Resistance to avermectins has been reported, which suggests use in moderation (Clark, 1995). Research on
ivermectin,
piperazine, and
dichlorvos in combinations also shows potential for toxicity (Toth, 2000). Avermectin has been reported to block LPS-induced secretion of
tumor necrosis factor,
nitric oxide,
prostaglandin E2, and increase of intracellular concentration of Ca2+ (Victorov, 2003). A proven ectoparasite mitigation method that stresses lab animals less than avermectin oral administration is definitely desirable.
Permethrin based treatments such as
MiteArrest may be a viable alternative.
Further Information
Get more info on 'Avermectin'.
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